Scientists Develop Blood Test that Detects Alzheimer’s Before Onset

From an article published in Dec 2022, in the journal of Biophysics and Computational Biology

Shea D, Colasurdo E, Smith A, Paschall C, Jayadev S, Keene CD, Galasko D, Ko A, Li G, Peskind E, Daggett V. SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2213157119. doi: 10.1073/pnas.2213157119. Epub 2022 Dec 9. PMID: 36490316.

Alzheimer’s is the most common neurological condition to affect seniors, with nearly 1/10 diagnosed. The problem with Alzheimer’s is there is no test for it. To get a diagnosis you have to first rule out all the other possible diseases and this takes months if not years.

Researchers at the University of Washington developed a test called SOBA that looks for clumps of a certain protein in blood and cerebrospinal fluid. SOBA correctly identified 52 of out 53 people with Alzheimer’s and even detected Alzheimer’s who had not yet shown signs of it.

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